Alpha Ketoglutarate

Alpha Ketoglutarate

What is Alpha Ketoglutarate?     

      α-Ketoglutaric acid is one of the two keto derivatives of glutaric acid, white fine crystalline powder. α-Ketoglutaric acid participates in the tricarboxylic acid cycle in organisms, produces amino acids, and can be used as a dietary supplement. α-Ketoglutaric acid is an important metabolic intermediate in the tricarboxylic acid cycle of microorganisms and a key node connecting carbon-nitrogen metabolism in cells. Its position in the cycle is after isocitrate and before succinyl-CoA. At this site, the anaplerotic reaction can achieve the purpose of replenishing this intermediate metabolite by producing α-ketoglutaric acid through the transamination of glutamate, and this purpose can also be achieved by glutamate dehydrogenase acting on glutamate. Glutamate can generate glutamine under the action of glutamine synthase, which uses one molecule of ATP to produce glutamyl phosphate; this intermediate is attacked by ammonia as a nucleophile to form glutamine and inorganic phosphate.

key Features

1. Enhanced Energy Production:

     ATP Synthesis: AKG powder is crucial for the production of ATP, the primary energy currency of the cell, by facilitating the Krebs cycle.

2. Antioxidant Properties:

    Cell Protection: Akg alpha ketoglutarate can help neutralize free radicals, reducing oxidative stress and potentially protecting cells from damage.

3. Muscle Growth and Recovery:

     Protein Synthesis: Alpha ketoglutaric acid can enhance protein synthesis
Reduced Muscle Fatigue: By improving energy efficiency at the cellular level, Akg alpha ketoglutarate might help reduce muscle fatigue during prolonged physical activities.

4. Kidney Health:

     Ammonia Detoxification: Alpha ketoglutarate powder plays a role in detoxifying ammonia in the kidneys, which can be beneficial for kidney function and overall renal health.

5. Collagen Formation:

     Skin Health: 2-OXOGLUTARIC ACID can assist in the production of proline, an amino acid essential for collagen synthesis, which is vital for skin, bone, and connective tissue health.

6. Immune System Support:

     Glutamine Production: AKG can be converted into glutamine, which is important for immune function, gut health, and muscle recovery.

7. Neuroprotection:

     Brain Health: There is some research suggesting that AKG might have neuroprotective effects, potentially aiding in the prevention of neurodegenerative diseases by supporting energy metabolism in brain cells.

8. Anti-Aging:

     Cellular Health: By enhancing mitochondrial function and reducing oxidative stress, AKG might contribute to slower aging at the cellular level.

9. Cardiovascular Health:

     Blood Pressure Regulation: Some studies indicate that Alpha-Ketoglutarate Powder might help in regulating blood pressure, although more research is needed in this area.

10. Metabolic Health:

     Weight Management: Preliminary studies suggest that AKG might influence metabolic pathways in a way that could support weight management efforts, though this area requires further exploration.

Applications

     1.Medical field:Alpha-Ketoglutarate Powder is an intermediate metabolite of the tricarboxylic acid cycle in organisms, and participates in the synthesis and energy metabolism of amino acids, vitamins and organic acids. It plays an important role in reducing the body loss of postoperative patients and long-term patients. In addition, α-ketoglutaric acid also has multiple physiological activities such as antioxidant and anti-inflammatory, can neutralize free radicals, and plays a key role in maintaining the health of organisms. α-ketoglutaric acid can also be used as a raw material for drugs to make antioxidants, immunomodulators and anti-inflammatory drugs, etc., which have a positive impact on the treatment and prevention of diseases.

     2.Agricultural field: It can act as a coenzyme of amino acid transaminase, participate in the metabolism and transport process of amino acids, thereby enhancing the absorption and utilization efficiency of nitrogen sources in the soil by plants. This can not only provide the nitrogen elements needed for plant growth, but also accelerate the growth rate of plants and increase yields. In addition, α-ketoglutaric acid can also affect the absorption of phosphorus and potassium elements. By regulating the growth and development of plant roots, α-ketoglutaric acid can enhance the plant's ability to absorb phosphorus and potassium elements in the soil, improve the growth of plants and enhance their yield stability.

     3.Food industry: It can be used as an ingredient in sports nutrition drinks to provide athletes with energy and supplement necessary nutrients. At the same time, α-ketoglutaric acid can also be used as an organic intermediate, biochemical reagent, and supporting reagent for measuring liver function, providing an important tool for biochemical research and medical diagnosis.

     4.Animal nutrition field:It can be used as a nutritional supplement to improve the growth performance and health of animals. Studies have shown that adding an appropriate amount of α-ketoglutaric acid to feed can promote protein synthesis, improve meat quality, and enhance immune system function, thereby improving the overall health of animals. In addition, α-ketoglutaric acid can also participate in the energy metabolism process, improve energy supply efficiency, reduce stress response, and help animals restore physiological balance faster.

Product Parameters

Package & Storage

      Our packing method is 1KG/Aluminium bags, 25kg/drum

      For some products that require special packaging during transportation, we will carry out more delicate packaging. For example, retinal needs to be stored at -20 °C, so we choose cold chain transportation during transportation; deoxyarbutin will change color during transportation, so we will Vacuum packing of deoxyarbutin