Pure 95% Food Grade Supplement CAS 151533-22-1 Levomefolate Calcium Calcium L-5-methyltetrahydrofolate Powder

 Levomefolate Calcium

What is Levomefolate Calcium?   

L-5-methyltetrahydrofolate calcium is a chemical substance with the molecular formula C20H23CaN7O6 and CAS number 151533-22-1. Its Chinese name is L-5-MTHF-Ca, and its English names include CALCIUM L-5-METHYLTETRAHYDROFOLATE, L-Methylfolate, calcium, etc., with trade names including Bodyfolin and Nutrifolin. This compound is the active metabolic form of folic acid and belongs to the derivatives of tetrahydrofolate calcium salt.

As a methylated form of folic acid, its molecular structure contains a complex of an L-glutamic acid group and a benzoyl group, existing as a calcium salt. Compared to ordinary folic acid, it can directly participate in one-carbon unit transfer reactions in vivo without metabolic conversion, and is mainly used in the pharmaceutical and nutritional supplement fields. Related formulations can be prepared by chemical synthesis, and some products exist in a highly stable crystalline form with good water solubility.

Feature

Highly Efficient in One-Carbon Unit Metabolism: L-5-Methyltetrahydrofolate calcium acts as a direct donor of methyl groups in the body, participating in key biochemical processes such as DNA synthesis and repair, gene expression regulation, and protein methylation. It supports cardiovascular and nervous system health by maintaining the normal functioning of the homocysteine-methionine cycle, converting harmful homocysteine ​​into beneficial methionine.

Supporting Nervous System Development and Function: This active folic acid is an essential cofactor in the methylation reactions during the synthesis of neurotransmitters (such as serotonin, dopamine, and norepinephrine), crucial for maintaining mood stability and cognitive function. It plays an irreplaceable role in fetal neural tube closure and brain development throughout pregnancy, and is the most effective form of prevention of neural tube defects.

Ensuring Normal Cell Division and Proliferation: By providing the methyl groups required for the synthesis of thymine and purine nucleotides, L-5-methyltetrahydrofolate calcium ensures the fidelity of genetic material replication, supports normal red blood cell production, and the health of all rapidly regenerating tissues.

Applications

Early Pregnancy Care and Eugenics: As the preferred form of folic acid supplementation for women planning pregnancy and pregnant women (especially in early pregnancy), it effectively prevents neural tube defects in the fetus (such as spina bifida and anencephaly). It is suitable for all women of childbearing age, especially MTHFR gene mutation carriers, ensuring the fetus receives sufficient available active folic acid to support normal development.

Cardiovascular and Neurological Health Support: Used for patients with hyperhomocysteinemia to reduce the risk of cardiovascular and cerebrovascular diseases (such as stroke and coronary heart disease) and neurodegenerative diseases (such as Alzheimer's disease). As a nutritional support program for the adjunctive treatment of mood disorders such as depression and anxiety, it improves symptoms by supporting neurotransmitter synthesis.

Nutritional Intervention for Special Populations:Used for individuals with folic acid metabolism disorders (MTHFR gene mutations) and those with folic acid deficiency due to long-term use of antiepileptic drugs or methotrexate, providing a directly usable form of folic acid. In the treatment of megaloblastic anemia, it is a more effective treatment option than regular folic acid, especially suitable for patients who do not respond well to conventional folic acid.

Product Parameters

For some products that require special packaging during transportation, we will carry out more delicate packaging. For example, retinal needs to be stored at -20 °C, so we choose cold chain transportation during transportation; deoxyarbutin will change color during transportation, so we will Vacuum packing of deoxyarbutin