Wholesale High Quality 98% Celastrol 98% Tripterygium Wilfordii Extract Cas 34157-83-0

Bitter Melon Extract Celastrol Powder

What is Bitter Melon Extract Celastrol Powder?    

Tripterygium wilfordii extract, also known as southern celastrine, is a pentacyclic triterpenoid natural bioactive product extracted from the root bark of *Tripterygium wilfordii*, a plant in the Celastraceae family. Its molecular formula is C29H38O4, and its CAS number is 34157-83-0. It appears as red crystals with a purity generally ≥98%. This substance induces apoptosis in cancer cells by inhibiting proteasome activity and possesses anti-inflammatory, anti-tumor, lipid metabolism-regulating, and anti-rheumatoid effects.

Feature

Potential Immunosuppression and Anti-inflammatory Effects: Tripterygium wilfordii directly inhibits the activation and proliferation of T and B lymphocytes, and reduces the expression of various inflammatory factors such as interleukin-2 and tumor necrosis factor-α. It inhibits the expression of inflammation-related genes at the transcriptional level by blocking the nuclear factor κB signaling pathway, with an effect comparable to some chemopreventive immunosuppressants.

Anti-tumor and Apoptosis Induction:This component can induce programmed cell death in various tumor cells (such as leukemia and breast cancer cells) through multiple pathways, including activating the Caspase cascade and regulating the Bcl-2/Bax protein balance. It can inhibit tumor angiogenesis and enhance the sensitivity of certain chemotherapeutic drugs.

Anti-inflammatory, Analgesic, and Anti-rheumatoid Arthritis Effects:Tripterygium wilfordii has significant inhibitory effects on both acute and chronic inflammation models. Its analgesic effect is related to the inhibition of prostaglandin synthesis and central analgesic pathways. In the treatment of rheumatoid arthritis, it can reduce synovial hyperplasia and cartilage destruction.

Applications

An effective proteasome inhibitor has been shown to induce apoptosis in cancer cells by inhibiting proteasome activity.

Product Parameters

For some products that require special packaging during transportation, we will carry out more delicate packaging. For example, retinal needs to be stored at -20 °C, so we choose cold chain transportation during transportation; deoxyarbutin will change color during transportation, so we will Vacuum packing of deoxyarbutin