Natural Bulk Banaba Leaf Extract Powder Corosolic Acid 1%-20% Corosolic Acid

Bitter Melon Extract Celastrol Powder

What is Bitter Melon Extract Celastrol Powder?    

Corosolic acid is a triterpenoid compound extracted from Lagerstroemia indica (commonly known as Panabala). Its chemical name is 2α-hydroxyursolic acid, with the molecular formula C30H48O4 and CAS number 4547-24-4. This substance is a white amorphous powder, readily soluble in organic solvents but sparingly soluble in water. It lowers blood sugar by activating glucose transport mechanisms, similar to insulin, hence its nickname "plant insulin." It also possesses multiple pharmacological activities, including weight loss, anti-inflammation, and inhibition of tumor cell growth.

Feature

Activation of Glucose Transporter:Corosolic acid directly activates the intracellular glucose transporter GLUT4, promoting glucose uptake and utilization by adipose and muscle cells, thereby rapidly lowering blood glucose levels. Its action is independent of insulin secretion, offering a unique advantage in improving insulin resistance.

Anti-inflammatory and Immunomodulatory Effects:This component reduces the release of inflammatory factors such as tumor necrosis factor-α and interleukin-6 by inhibiting the nuclear factor κB and MAPK signaling pathways, alleviating chronic low-grade inflammation. It also regulates macrophage polarization, improving obesity-related metabolic inflammation.

Antioxidant and Pancreatic β-cell Protection:Corosolic acid has the ability to scavenge free radicals, reducing oxidative stress damage to pancreatic β-cells. It inhibits α-glucosidase activity, delaying carbohydrate digestion and absorption, and helping to stabilize postprandial blood glucose levels.

Applications

Blood Glucose Management and Diabetes Support Products: Used as a core ingredient in health foods or functional foods to assist in blood sugar regulation, especially suitable for patients with type 2 diabetes and prediabetes. Often combined with ingredients such as chromium and bitter melon extract to exert a synergistic blood sugar-lowering effect.

Weight Control and Metabolic Health Products: Used in compound formulas to improve metabolic syndrome, helping to reduce visceral fat accumulation by enhancing insulin sensitivity. Added to sports nutrition products to promote glycogen recovery and performance enhancement after exercise.

Anti-inflammatory Skin Care and Oral Care: Utilizes its anti-inflammatory properties in skin care products for acne and sensitive skin to reduce redness and irritation. Used in toothpaste or mouthwash formulas to help control gingivitis and oral ulcers.

Drug Development and Research Applications: Used as a lead compound in the development of novel blood sugar-lowering or anti-inflammatory drugs, currently in the preclinical research stage. Its potential as a plant growth regulator is being studied in the agricultural field.

Product Parameters

For some products that require special packaging during transportation, we will carry out more delicate packaging. For example, retinal needs to be stored at -20 °C, so we choose cold chain transportation during transportation; deoxyarbutin will change color during transportation, so we will Vacuum packing of deoxyarbutin