Supplement PEA Palmitoylethanolamide Pea Palmitoyl Ethanolamide CAS 544-31-0

Palmitoylethanolamide

What is Palmitoylethanolamide?   

Palmitoylethanolamide, also known as pamidol, is industrially synthesized from palm oil via high-pressure hydrolysis and acylation. This process uses no chemical solvents and results in a product purity exceeding 99%.

This substance is an endogenous fatty acid amide that exerts anti-inflammatory, analgesic, and neuroprotective effects by activating PPAR-α receptors. It can regulate hippocampal neuron development and hypothalamic-pituitary-adrenal axis function. Studies have shown that it can improve depressive-like behaviors induced by chronic stress.

key Features

1. Anti-inflammatory Effects
PEA activates intracellular PPAR-α receptors, inhibiting the release of pro-inflammatory cytokines (such as TNF-α and IL-6), thereby reducing inflammatory responses. Studies have shown significant effects on chronic inflammatory conditions (such as enteritis and arthritis).

2. Analgesic Effects
PEA is particularly effective for neuropathic pain (such as sciatica and diabetic neuropathy). By modulating glial cell activity and reducing pain signal transmission, its effectiveness is comparable to that of some medications.

3. Neuroprotective Effects
PEA can reduce oxidative stress and neuronal damage. Clinical trials have shown that it may delay the progression of multiple sclerosis and Alzheimer's disease, but further verification is needed.

4. Skin Health
Topical application of PEA can soothe skin inflammation, such as eczema and dermatitis, strengthen the skin barrier function, and reduce redness, swelling, and itching.

Applications

1. Chronic Pain Management
Arthritis/Fibromyalgia: Inhibits synovial inflammation, improving stiffness and pain.
Postoperative Pain: Helps reduce opioid dependence.

2. Neuropathy Treatment

It has been shown to alleviate conditions such as diabetic peripheral neuropathy and trigeminal neuralgia, often used in combination with conventional medications.

3. Skin Care

It can be added to skincare products to treat sensitive skin and rosacea. Long-term use can reduce recurrence rates.

4. Potential Research Directions

Animal studies have shown protective effects against Parkinson's disease and post-stroke damage, but human studies are still in the early stages.

Product Parameters

For some products that require special packaging during transportation, we will carry out more delicate packaging. For example, retinal needs to be stored at -20 °C, so we choose cold chain transportation during transportation; deoxyarbutin will change color during transportation, so we will Vacuum packing of deoxyarbutin