Wholesale Price Rotenone Root Extract Rotenone CAS 83-79-4 Powder Price Rotenone

Rotenone

What is Rotenone?    

Rotenone is a natural organic compound with the chemical formula C23H22O6 and CAS Registry Number 83-79-4. It is mainly found in the roots of plants in the genus *Rotenone* (Fabaceae family) and the stems, leaves, and seeds of  Dioscorea opposita. It is also distributed in the roots of the traditional Chinese medicinal herbs Dioscorea opposita seeds, Salvia miltiorrhiza seeds, and  Spatholobus suberectus. Its melting point is 159-164℃. It is almost insoluble in water, unstable, and easily decomposes in alkaline substances. When exposed to light and air, it oxidizes, gradually changing the solution from colorless to yellow, orange, and finally deep red, precipitating dehydrorotenone and rotenedione crystals, while still retaining insecticidal activity.

As a selective insecticide, this substance inhibits the activity of NADH dehydrogenase in the mitochondrial respiratory chain of pests, blocking cellular energy metabolism. It has contact and stomach poison effects on aphids, sorghum aphids, and other pests.

Feature

Inhibition of the cellular respiratory chain: Rotenone specifically inhibits mitochondrial complex I (NADH dehydrogenase), blocking electron transport and ATP synthesis, leading to cellular energy depletion and death. This effect is particularly rapid in insects and fish, and the same target is also present in mammalian cells.

Neurotoxicity: Due to the extremely high energy requirements of nerve cells, rotenone can selectively cause damage to dopaminergic neurons. Long-term exposure may induce Parkinson's disease-like symptoms. Its lipid solubility allows it to easily cross the blood-brain barrier, exacerbating the risk of central nervous system damage.

Insecticidal and pisicidal activity: It has both contact and stomach poison effects on insects, with rapid knockdown and low resistance development. In water, it can rapidly enter the circulatory system of fish through gill tissue, causing asphyxiation and death.

Applications

Organic agricultural pesticides, as plant-derived pesticides, are used in organic agriculture to control pests such as aphids and cabbage caterpillars. They have short residual periods and are environmentally friendly. Strict control of concentration and application intervals is necessary to avoid harming non-target organisms such as bees.

Aquaculture management pond cleaning agents are used to remove wild fish, snails, and other predatory organisms from aquaculture ponds. Their natural degradation characteristics reduce the impact on subsequent aquaculture. After application, adequate aeration and residue testing are required to ensure safety before introducing commercially viable fish species.

Scientific research and disease model construction: Used in laboratories to construct cell or animal models of Parkinson's disease and study the mechanisms of neurodegenerative diseases. Serves as a tool for mitochondrial function research, exploring energy metabolism-related diseases.

Strictly restricted special uses: Formerly used for the control of ectoparasites in livestock (e.g., sheep baths), but gradually being replaced due to toxicity issues. Strictly prohibited for use as a food additive, health product, or everyday pesticide; ordinary consumers should not come into contact with the raw material.

For some products that require special packaging during transportation, we will carry out more delicate packaging. For example, retinal needs to be stored at -20 °C, so we choose cold chain transportation during transportation; deoxyarbutin will change color during transportation, so we will Vacuum packing of deoxyarbutin