Factory Supply D-Glucuronic Acid CAS 6556-12-3 D Glucoronic Acid Powder

D-Glucuronic Acid  

What is D-Glucuronic Acid ?   

D-glucuronic acid, also known as uric acid, is an organic compound with a chemical formula of C6H10O7, a molecular weight of 194.14, and a CAS registration number of 6556-12-3. This substance is a white solid or powder at room temperature, with a density of 2.0±0.1 g/cm³, a melting point of 159-161°C, and is soluble in water (100mg/mL). It needs to be stored in shade.

As a biochemical reagent and chemical reference substance, it is mainly used in chemical/biochemical research and content determination of chondroitin sulfate A sodium and sodium hyaluronate. It exists in the form of furan ring 3,6-lactone in vivo, which can be generated by the enzymatic oxidation of UDP glucose, and participates in the synthesis of glycosaminoglycans such as heparin and hyaluronic acid. This compound has the physiological function of binding toxins and expelling them, and has anti-inflammatory effects on the skin as a glucuronolactone derivative.

Feature

liver detoxification function
As a key substrate for glucuronidation, it binds to drugs, bilirubin and other endogenous toxins, significantly improving water solubility. By activating the UDP-glucuronosyltransferase family, it promotes the excretion of foreign substances through bile and urine, increasing the clearance rate of drugs such as acetaminophe by 3.2 times.

Glycosaminoglycan synthesis
As the basic unit of macromolecules such as hyaluronic acid and chondroitin sulfate, it is alternately connected through β1-3 and β1-4 glycosidic bonds to form a polymer skeleton. Experiments have confirmed that its supply directly determines the elongation efficiency of glycosaminoglycan chains and affects the mechanical properties of connective tissue.

antioxidant defense
Shunts glucose metabolism through the pentose phosphate pathway and reduces the production of advanced glycation end products. Its carboxyl group can chelate transition metal ions, inhibit the formation of hydroxyl radicals, and reduce the level of oxidative stress marker malondialdehyde by 41%.

Applications

Pharmaceutical preparation development
As the core component of hepatoprotective drugs, it is used to treat toxic liver damage and shorten the time for alanine aminotransferase to normalize. Prodrugs can be prepared in combination with psilocybin, which can hydrolyze and release active ingredients after passing through the blood-brain barrier, thereby improving bioavailability.

Functional skin care products
In the anti-aging essence, it is enzymatically converted into glucuronic acid by skin flora, which stimulates fibroblasts to increase collagen synthesis. Its carboxyl group combines with the hydrogen bond network of the stratum corneum to reduce transepidermal water loss.

Diagnostic reagent raw materials
As a β-glucuronidase substrate, it is used to detect microbial contamination such as E. coli. It is used to prepare targeted contrast agents in tumor diagnosis to specifically label lysozyme-overexpressing diseased tissues.

Biomaterial modification
Swelling degree of hydrogels prepared by grafting onto chitosan chains via esterification reaction. It is used as a cartilage scaffold coating in tissue engineering to promote the differentiation efficiency of bone marrow mesenchymal stem cells into chondrocytes.

For some products that require special packaging during transportation, we will carry out more delicate packaging. For example, retinal needs to be stored at -20 °C, so we choose cold chain transportation during transportation; deoxyarbutin will change color during transportation, so we will Vacuum packing of deoxyarbutin